International Prostatitis Research Foundation
- Recent Key Papers
- Basic Science
- UCPPS (IC/PBS + CP/CPPS)
- Medications
- Images
- CPCRN
- Other
- Resources
Prostatitis - Key Scientific Papers
The International Prostatitis Research Foundation provides this service to you in order to spread knowledge of recent research in this area. You will need Acrobat Reader to access these papers, so if you don't have it already, download it here.
Wise-Anderson Protocol (Stanford Protocol) / Trigger Points
- 2004 - Urologic Myofascial Pain Syndromes (Ragi Doggweiler-Wiygul, MD)
- 2004 - Myofascial Pain Syndromes – Trigger Points
- 2005 - Myofascial Trigger Point Release and Paradoxical Relaxation training treatment of chronic pelvic pain
- 2005 - The Stanford Protocol (paper presented at AUA 2005)
- 2006 - Sexual Dysfunction in Chronic Prostatitis/CPPS: Improvement after Trigger Point Release + Paradoxical Relaxation Training
- 2008 - Muscle Tenderness in Men With Chronic Prostatitis
- 2008 - Uncovering The Biochemical Milieu Of Myofascial Trigger Points Using In Vivo Microdialysis
- 2010 - Myofascial pain syndrome in the pelvic floor: A common urological condition
- 2011 - 6-Day Intensive Treatment Protocol for Refractory Chronic Prostatitis/Chronic Pelvic Pain Syndrome Using Myofascial Release and Paradoxical Relaxation Training
Stress and Nerves
- 1995 - Stress & Inflammation (Hypothalamic-Pituitary-Adrenal Axis & Immune-Mediated Inflammation)
- 2000 - Biofeedback, Pelvic Floor & Bladder Training
- 2001 - Nerves, Stress, CFS/Fibromyalgia and Chronic Pain
- 2001 - Role Of Afferent Neurons In Stress Induced Degenerative Changes Of The Bladder
- 2006 - Neuroimmunoendocrine circuitry (HPA axis, cortisol, stress)
- 2008 - Psychometric Profiles and HPA Axis Function in Men with CP/CPPS
Genetics
Pharmacology
Prostatitis - The Basic Science Background
Urology
Psychology
Neurology
Mast Cells
- 1997 - How To Diagnose
IC Based On Mast Cell Biopsy Findings
- 2000 - Basophils and Mast Cells
- 2000 - Mast Cells and Neurogenic Cystitis
- 2001 - CP/CPPS and Immunology Study
- 2001 - The Diverse Role of Mast Cells
- 2004 - Critical Role of Mast Cells in Diseases
- 2004 - Mast cells as targets of corticotropin releasing factor (stress-mast cells crosstalk)
- 2007 - The Mast Cell in Interstitial Cystitis
Prostatitis - Overlap of the Urologic Chronic Pelvic Pain Syndromes: IC/PBS and CP/CPPS
IC/PBS and CP/CPPS — The Same Disease?
- 2001 - Interstitial Cystitis: Past and Future
- 2001 - IC: Current Controversies
- 2001 - IC: Current issues in Diagnosis
- 2001 - IC in Males
- 2001 - IC in Identical Twins
- 2002 - Similarities Between Interstitial Cystitis & Male Chronic Pelvic Pain Syndrome
- 2002 - Interstitial cystitis, pelvic pain, & the relationship to myofascial pain
Papers on Medications and Phytopharmaceuticals used to treat UCPPS
General
- 2001 - Immunomodulation of Autoimmune & Inflammatory Diseases w/ Immune Globulin
- 2001 - New agents for the medical treatment of interstitial cystitis
- 2007 - Treating IC/PBS (many of these drugs also treat CP/CPPS)
Phytochemicals & Alternative Treatment of Prostatitis
- 1999 - Quercetin In Men With Category III Chronic Prostatitis
- 2000 - Modulation Of Apoptotic & Inflammatory Genes By Bioflavonoids
- 2000 - Integrative Urology: A Spectrum Of Complementary And Alternative Therapy
- 2001 - Beta-endorphin & prostaglandin e2 levels in prostatic fluid of chronic prostatitis pts (effect of Prosta-Q)
Opioids and Pain Suppression
Antibiotics and Alpha-Blockers
Prostatitis Diagrams - Pelvic Muscles
The muscle diagrams on this page (used with permission) relate to the recent (2005/6) research from Stanford University that found over 70% of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are greatly helped by a combination of trigger point manipulation and relaxation training. This means that myofascial trigger point assessment and release therapy in conjunction with paradoxical relaxation therapy is far superior to traditional therapy and should be used in any multimodal treatment of this enigmatic syndrome.
Male Pelvic Floor Diagrams
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General male pelvic anatomy. Click diagram to see enlarged view. Image from free medical images database. |
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Another general view. Image from free medical images database. |
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Another general view. Image from free medical images database. |
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Here is a diagram of an overhead view
looking down into the pelvic floor to print for your Physical
Therapist. Ask him/her to note the locations of your TrPs.
Image used with permission. |
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The main pelvic floor muscles from below. Notice the anal sphincter surrounded by the hammock-shaped levator ani. Image used with permission. |
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The large levator ani muscles are divided into several sections, each with different names. The levator ani are bilateral muscles composed of the right and left pubococcygeus muscle anteriorly, and the iliococcygeus, in the midpelvis. Image used with permission. |
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This nicely illustrates the levator's hammock shape. Image used with permission. |
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Behind the levators are the coccygeus muscles. The coccygeus muscle is a thin triangular sheet of muscle continuous with the iliococcygeous muscle anteriorly, originating from ischial spine and sacrospinous ligament, and inserting on the lower sacral margin and coccyx. The coccygeous muscle combines with the levator ani muscle to form the pelvic diaphragm. Image used with permission. |
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The obturator internus muscle is a thick, fan-shaped muscle within the pelvis that covers the obturator foramen, attaching around its perimeter, and to the thick obturator membrane. The obturator vessels and nerves lie on the surface of the muscle, exiting the true pelvis via the obturator canal. Sloping downward from antero-superiorly above, the muscle leaves the true pelvis by curving acutely around the ischium, below its spine through the lesser sciatic foramen, to reach the greater trochanter of the femur. Image used with permission. |
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Here superimposed and attached to the tendinous arches on each side, is the pelvic diaphragm formed by the levator ani muscles. Levator ani muscles actively support the pelvic contents, compressing the urethra by elevating the pelvic floor, and maintaining the anorectal angle by pulling the anorectal junction forward. Relaxation of these muscles allows evacuation of the bladder and rectum. By increasing the intra-abdominal pressure even more through simultaneous contraction of the diaphragm and abdominal wall muscles, they distend the pelvic floor downward, opening its appetures. Image used with permission. |
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Notice the route of the pudendal nerve. Image used with permission. |
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The pudendal nerve from below. Image used with permission. |
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A diagram from the book by David Wise called "A Headache in the Pelvis". Shows associations of trigger points and pain distribution. Image used with author's permission. |
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Another diagram from the book by David Wise called "A Headache in the Pelvis". This shows one of many diagrams from this unique book that demonstrate how internal trigger points associated with male chronic pelvic pain are located and treated. Image used with author's permission. |
Chronic Prostatitis Collaborative Research Network (CPCRN)
The NIDDK formed the Chronic Prostatitis Collaborative Research Network (CPCRN) in 1997. Work continues under the MAPP network.
Prostatitis Papers from CPCRN group, 2002 Meeting
- 2002 - Overview summary statement on CPPS Dec 2002
- 2002 - Classification and demographics of prostatitis — Discussion
- 2002 - Chronic prostatitis: epidemiology and role of infection — Discussion
- 2002 - Development and validation of the NIH chronic prostatitis symptom index — Discussion
- 2002 - Clinical evaluation of men w/ chronic prostatitis/chronic pelvic pain syndrome — Discussion
- 2002 - Antimicrobial therapy for bacterial and nonbacterial prostatitis — Discussion
- 2002 - Role of a-blockers in the treatment of chronic prostatitis — Discussion
- 2002 - Inflammation and anti-inflammatory therapy in chronic prostatitis — Discussion
- 2002 - Phytotherapy in chronic prostatitis — Discussion
- 2002 - Heat therapy in the treatment of prostatitis — Discussion
- 2002 - Bladder training biofeedback and pelvic floor myalgia — Discussion
Other Papers relating to Prostatitis and CP/CPPS
Miscellaneous
- 2000 - Overactive Bladder (OAB)
- 2001 - Prostatitis: State of the Art
- 2002 - Theories of Prostatitis Etiology
- 2002 - Cytokine Polymorphisms in Chronic Prostatitis/CPPS
- 2007 -
Management of Men diagnosed with Chronic Prostatitis/CPPS who
have failed Traditional Management
- 2007 -
Prostatitis: The Sex Destroyer (from Best Life magazine)
- 2009 - UPOINT Clinical Phenotyping of CP/CPPS Patients
- 2011 - DABBEC Phenotyping System (DPS) of CP/CPPS Patients
Infection Theory of Prostatitis
Links to Internet Resources
These are the only websites we recommend at the moment:













